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KMID : 0525720100150020088
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Journal of Chitin and Chitosan
2010 Volume.15 No. 2 p.88 ~ p.91
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Inhibitory Effect of Chitosan Oligosaccharides on Sialidase Activity In vitro
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Park Jae-Kweon
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Abstract
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Inhibition studies have been exploited in the design of a potent polyvalent inhibitor of the sialidase. A study was conducted to investigate the inhibitory effect of chitosan-oligosaccharides referred to (GlcN)n on Sialidase (SDase) activity in vitro. Major component of (GlcN)n obtained by enzymatic digestion of chitosan was identified to be (GlcN)n, n = 2-5 by matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-TOF MS) analysis. Various parameters were monitored for optimization of the inhibitory activity of (GlcN)n and other relative compounds on SDase. The results provided evidence for inhibitory effect; (GlcN)n in suppressing SDase activity in vitro and also provided useful information for the further development of chitosanoligosaccharides (GlcN)n as a potential antiviral agent.
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KEYWORD
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chitosan oligosaccharide, sialidase, SDase, MALDI-TOF MS
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